Regenerative Medicine

Professor Dr. med. Hubert Löwenheim

we have relocated to:

http://www.uni-oldenburg.de/humanmedizin/uniklinik-hno/forschung/

Department of Otolaryngology, Head and Neck Surgery
Tübingen Hearing Research Centre
Elfriede-Aulhorn-Strasse 5
D-72076 Tübingen
Germany

Phone: +49 (0)7071/29-88088
Fax: +49 (0)7071/29-3311
hubert.loewenheim@uni-tuebingen.de

The Löwenheim group is located at the University of Tübingen Medical Centre, Department of Otolaryngology, Head & Neck Surgery. The group has exclusive access to laboratories for biochemical, cell biological, molecular-biological and physiological work. There are three rooms equipped with biosafety cabinets for cell and organ culture, several shared central equipment core rooms, and two audio booths for small animals fully equipped for sophisticated auditory electrophysiology. There are three fluorescence microscopes (one LSM) exclusively used by the Löwenheim group. There is access to LSM, TEM and SEM electron microscopes located anatomical department of the University of Tübingen. Animal care facility (SPF) is located within the building. The medical school Tübingen has several core facilities, including DNA sequencing, microarray, laser dissection, FACS, PET, MET, Proteomics and transgenic mouse facility.

The group has established several inner ear assay platforms: murine inner ear derived cell lines, cochlear progenitor cell expansion, in vitro cochlea spiral ganglion cell model, in vitro culture model for the whole inner ear for drug screening; in vivo hearing loss models and local drug application technology.

Senior staff:

Prof. Dr. med. Hubert Löwenheim, Leader of the project team “Regenerative Medicine” at the Tübingen Hearing Research Center, Stellvertretender Ärztlicher Direktor, Klinik für Hals-, Nasen- und Ohrenheilkunde Tübingen.

Priv.-Doz. Dr. phil. nat. Marcus Müller, Senior scientist with too many years of experience in various in vivo animal models, inner ear local drug application technology, and functional assessment of the inner ear in birds and mammals.

Research Interest

  • Regeneration in the inner ear
  • Stem cell research
  • Water regulation in the inner ear
  • Treatment of noise induced hearing loss
  • Protection of hair cell loss after acoustic or ototoxic trauma
  • Development of organ culture methods to reduce animal experiments
  • Improvement of cochlear implant performance

National and international scientific partners

http://thrc.hno.medizin.uni-tuebingen.de/groups/home

Fero and Roberts, Fred Hutchinson Cancer Research Center, Seattle USA
Gharabaghi, Klinik für Neurochirurgie am Universitätsklinikum Tübingen
Kumagami, Nagasaki University, Japan
Heller, Stanford University, Stanford USA
Hirt, Anatomisches Institut der Universität Tübingen
Rask-Andersen, Department of Otosurgery, University Hospital Uppsala, Sweden
Schlosshauer, NMI Reutlingen
Schrattenholz, ProteoSys AG Mainz
Senn, Inselspital Bern, Schweiz
Tatagiba, Klinik für Neurochirurgie am Universitätsklinikum Tübingen
Wiesmüller, EMC microcollections GmbH Tübingen

Publications

Pubmed Hubert Löwenheim External Link

Pubmed Marcus Müller External Link

Selected Publications

Group Members

Scientific Grants

Present grants:

2013-2017 :
Grant giving institution: EU FP7
Title: Human stem cell applications for the treatment of hearing loss. http://otostem.org

2012-2015 :
Grant giving institution: EU FP7
Title: Nanotechnology based cochlear implant with gapless interface to auditory neurons. http://nanoci.org/index.php

2011-2014 :
Grant giving institution: BMBF
Title: BioTransporter - Effizienter Wirkstofftransport in biologischen Systemen Verbundprojekt: OtoPep, Peptid-Nanomatrix als Träger für siRNA zur Behandlung von Erkrankungen des zentralen und sensorischen Nervensystems.

2008- :
Grant giving institution: BMBF Klinische Prüfung BEMED
Title: Durchführung einer klinischen Prüfung: „Therapie des M. Menière mit Betahistin: eine plazebo-kontrollierte Dosisfindungsstudie“ Studienzentrum Tübingen.

Selected recent previous grants:

2011-2012 :
Grant giving institution: Stiftung SET
Title: Entwicklung eines auf Stammzellen basierten Modells des Innenohres: In vitro Modell für die Prüfung von Medikamenten zur Behandlung von Innenohrerkrankungen als Ersatzmethode zum Tierversuch.

2010-2011 :
Grant giving institution: Universität Tübingen IZKF
Title: Untersuchung zur Regulation des Neuritenwachstums im Spiralganglion des Innenohres durch neurotrophe Faktoren.

2009-2010 :
Grant giving institution: Proteosys AG
Title: Otoprotektion in vitro.

2007-2009 :
Grant giving institution: Ministerium für Ernährung und ländlichen Raum, Baden-Württemberg
Title: Entwicklung einer Organkultur der Cochlea adulter Mäuse

2005-2008 :
Grant giving institution: Sanitätsamt der Bundeswehr
Title: Untersuchungen des akuten Lärmtraumas beim Meerschweinchen.

November 2006- April 2008 :
Grant giving institution: BMBF
Title: Axonale Regeneration im zentralen Nervensystem in einer aktiven Nanofasermatrix (in Zusammenarbeit mit der Klinik für Neurochirurgie und EMC micrcollections GmbH).

   
   
Last modified: 26.02.2015 13:16