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Molecular Physiology of Hearing

Prof. Dr. Marlies Knipper

Department of Otolaryngology, Head and Neck Surgery
Tübingen Hearing Research Centre
Elfriede-Aulhorn-Strasse 5
D-72076 Tübingen
Germany

Phone: +49 (0)7071 - 29 88244
Fax: +49 (0)7071 - 29 4950
marlies.knipper@uni-tuebingen.de

Research Interest

Our primary research focuses on the critical period of inner ear development prior to cochlear functioning. This developmental period comprises the stage when the immature organ evolves into a functional adult organ of Corti via synchronous morphogenetic processes. With biological techniques we analyze epigenetic factors (growth and thyroid), and transcription factors (cis-trans-elements) regulating inner ear developmental phases.

Further research interests are directed towards the upregulation processes of protein structures of the outer hair cell (motor and cytoskeletal proteins) during phenotypical outer hair cell differentiation prior to hearing onset.

Other projects include studying the molecular mechanisms behind trauma to the auditory system. The molecular changes following sensory trauma and the subsequent response of the central nervous system are poorly understood. We are focused on finding a molecular tool for monitoring the features of excitability which occur following acoustic trauma or ototoxic insult to the auditory system. Concentrated sodium salicylate is known to induce high frequency hearing loss and tinnitus in humans and rodents. Tinnitus perception is known to be associated with altered neuronal excitability in peripheral and central auditory neurons.

Of particular interest are genes that alter their expression pattern during activity-induced changes in synaptic efficacy and plasticity. The immediate-early genes brain derived neurotrophic factor (BDNF), the activity-dependent cytoskeletal protein (Arg3.1, also known as Arc), and c-Fos are known to be affected by changes in excitability and plasticity. We are using RT-PCR, in situ hybridization and immunohistochemistry to study these genes following induction of tinnitus.

Research Scientists

Molecular Neurobiology


Monika Gaus, administration
Phone: +49 (0) 7071 - 29 88243


Kerstin Just, administration
Phone: +49 (0) 7071 - 29 29 88242


Dr. Ulrike Zimmermann, research scientist
Phone: +49 (0) 7071 - 29 88245


Dr. Wibke Singer, research scientist
Phone: +49 (0)7071 - 29 88246


Dr. med. Carina Meiser, research scientist
Phone: +49 (0)7071 - 29 88268


Hyun-Soon Geisler, Technician
Phone: +49 (0)7071 - 29 88268


Iris Köpschall, Technician
Phone: +49 (0)7071 - 29 88245


Karin Rohbock, Technician
Phone: +49 (0)7071 - 29 88245


Dario Campanelli, PhD student
Phone: +49 (0)7071 - 29 88246


Ksenya Varakina, PhD student
Phone: +49 (0)7071 - 29 88202


Kamyar Kasini, PhD student
Phone: +49 (0)7071 - 29 88202


Diletta Pozzi, MSc student
Phone: +49 (0)7071 - 29 88202


Benjamin Lange, IT Support
Phone: +49 (0)7071 - 29 88268

Electrophysiology


Dr. Lukas Rüttiger (Head of Lab)
Phone: +49 (0)7071 - 29 88260


Dr. Mirko Jaumann, research scientist
Phone: +49 (0)7071 - 29 88184


Lewis, Sze Chim Lee, PhD student
Phone: +49 (0)7071 - 29 88195

Publications

Cimerman J, Waldhaus J, Harasztosi C, Duncker SV, Dettling J, Heidrych P, Bress A, Gampe-Braig C, Frank G, Gummer AW, Oliver D, Knipper M, Zimmermann U
"Generation of somatic electromechanical force by outer hair cells may be influenced by prestin-CASK interaction at the basal junction with the Deiter's cell."
Histochem Cell Biolp(2013)
Johnson SL, Kuhn S, Franz C, Ingham N, Furness DN, Knipper M, Steel KP, Adelman JP, Holley MC, Marcotti W
"Presynaptic maturation in auditory hair cells requires a critical period of sensory-independent spiking activity."
Proc Natl Acad Sci U S Ap(2013)
Rüttiger L, Singer W, Panford-Walsh R, Matsumoto M, Lee SC, Zuccotti A, Zimmermann U, Jaumann M, Rohbock K, Xiong H, Knipper M
"The reduced cochlear output and the failure to adapt the central auditory response causes tinnitus in noise exposed rats."
PLoS One8pe57247(2013)
Singer W, Zuccotti A, Jaumann M, Lee SC, Panford-Walsh R, Xiong H, Zimmermann U, Franz C, Geisler HS, Köpschall I, Rohbock K, Varakina K, Verpoorten S, Reinbothe T, Schimmang T, Rüttiger L, Knipper M
"Noise-induced inner hair cell ribbon loss disturbs central arc mobilization: a novel molecular paradigm for understanding tinnitus."
Mol Neurobiol47p261-79(2013)
Eckrich T, Varakina K, Johnson SL, Franz C, Singer W, Kuhn S, Knipper M, Holley MC, Marcotti W
"Development and function of the voltage-gated sodium current in immature mammalian cochlear inner hair cells."
PLoS One7pe45732(2012)
Föller M, Jaumann M, Dettling J, Saxena A, Pakladok T, Munoz C, Ruth P, Sopjani M, Seebohm G, Rüttiger L, Knipper M, Lang F
"AMP-activated protein kinase in BK-channel regulation and protection against hearing loss following acoustic overstimulation."
FASEB Jp(2012)
Jaumann M, Dettling J, Gubelt M, Zimmermann U, Gerling A, Paquet-Durand F, Feil S, Wolpert S, Franz C, Varakina K, Xiong H, Brandt N, Kuhn S, Geisler HS, Rohbock K, Ruth P, Schlossmann J, Hütter J, Sandner P, Feil R, Engel J, Knipper M, Rüttiger L
"cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function."
Nat Medp(2012)
Kammerer R, Ruettiger L, Riesenberg R, Schaeuble C, Krupar R, Kamp A, Sunami K, Eisenried A, Hennenberg M, Grunert F, Bress A, Battaglia S, Schrewe H, Knipper M, Schneider MR, Zimmermann W
"Loss of the mammal-specific tectorial membrane component CEA cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies."
J Biol Chemp(2012)
Knipper M, Müller M, Zimmermann U
"Molecular Mechanism of Tinnitus."
In: Springer Handbook of Audidory Research: TINNITUS (Eggermont JJ, Zeng F-G, Popper AN, Fay RR, eds). Springer New York Heidelberg, Dordrecht London, pp. 59-82. (2012)
Kurt S, Sausbier M, Rüttiger L, Brandt N, Moeller CK, Kindler J, Sausbier U, Zimmermann U, van Straaten H, Neuhuber W, Engel J, Knipper M, Ruth P, Schulze H
"Critical role for cochlear hair cell BK channels for coding the temporal structure and dynamic range of auditory information for central auditory processing."
FASEB Jp(2012)
Schraven SP, Franz C, Rüttiger L, Löwenheim H, Lysakowski A, Stoffel W, Knipper M
"Altered Phenotype of the Vestibular Organ in GLAST-1 Null Mice."
J Assoc Res Otolaryngol13p323-33(2012)
Satheesh SV, Kunert K, Rüttiger L, Zuccotti A, Schönig K, Friauf E, Knipper M, Bartsch D, Nothwang HG
"Retrocochlear function of the peripheral deafness gene Cacna1d."
Hum Mol Genetp(2012)
Zak M, Breß A, Brandt N, Franz C, Ruth P, Pfister M, Knipper M, Blin N
"Ergic2, a brain specific interacting partner of otoferlin."
Cell Physiol Biochem29p941-8(2012)
Zuccotti A, Kuhn S, Johnson SL, Franz C, Singer W, Hecker D, Geisler HS, Köpschall I, Rohbock K, Gutsche K, Dlugaiczyk J, Schick B, Marcotti W, Rüttiger L, Schimmang T, Knipper M
"Lack of Brain-Derived Neurotrophic Factor Hampers Inner Hair Cell Synapse Physiology, But Protects against Noise-Induced Hearing Loss."
J Neurosci32p8545-8553(2012)
Buerbank S, Becker K, Becker CM, Brandt N, Engel J, Knipper M, Schick B, Dlugaiczyk J
"Developmental regulation of glycine receptors at efferent synapses of the murine cochlea."
Histochem Cell Biolp(2011)
Johnson SL, Eckrich T, Kuhn S, Zampini V, Franz C, Ranatunga KM, Roberts TP, Masetto S, Knipper M, Kros CJ, Marcotti W
"Position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cells."
Nat Neurosci14p711-7(2011)
Zampini V, Rüttiger L, Johnson SL, Franz C, Furness DN, Waldhaus J, Xiong H, Hackney CM, Holley MC, Offenhauser N, Di Fiore PP, Knipper M, Masetto S, Marcotti W
"Eps8 regulates hair bundle length and functional maturation of Mammalian auditory hair cells."
PLoS Biol9pe1001048(2011)
Gebhart M, Juhasz-Vedres G, Zuccotti A, Brandt N, Engel J, Trockenbacher A, Kaur G, Obermair GJ, Knipper M, Koschak A, Striessnig J
"Modulation of Cav1.3 Ca2+ channel gating by Rab3 interacting molecule."
Mol Cell Neurosci44p246-59(2010)
Johnson SL, Franz C, Kuhn S, Furness DN, Rüttiger L, Münkner S, Rivolta MN, Seward EP, Herschman HR, Engel J, Knipper M, Marcotti W
"Synaptotagmin IV determines the linear Ca2+ dependence of vesicle fusion at auditory ribbon synapses."
Nat Neurosci13p45-52(2010)
Knipper M, Zimmermann U, Müller M
"Molecular aspects of tinnitus."
Hear Res266p60-9(2010)
Lubka-Pathak M, Shah AA, Gallozzi M, Müller M, Zimmermann U, Löwenheim H, Pfister M, Knipper M, Blin N, Schimmang T
"Altered expression of securin (Pttg1) and serpina3n in the auditory system of hearing-impaired Tff3-deficient mice."
Cell Mol Life Scip(2010)
Vandael DH, Marcantoni A, Mahapatra S, Caro A, Ruth P, Zuccotti A, Knipper M, Carbone E
"Ca(v)1.3 and BK channels for timing and regulating cell firing."
Mol Neurobiol42p185-98(2010)
Zampini V, Johnson SL, Franz C, Lawrence ND, Münkner S, Engel J, Knipper M, Magistretti J, Masetto S, Marcotti W
"Elementary properties of CaV1.3 Ca(2+) channels expressed in mouse cochlear inner hair cells."
J Physiol588p187-99(2010)
Heidrych P, Zimmermann U, Kuhn S, Franz C, Engel J, Duncker SV, Hirt B, Pusch CM, Ruth P, Pfister M, Marcotti W, Blin N, Knipper M
"Otoferlin interacts with myosin VI: implications for maintenance of the basolateral synaptic structure of the inner hair cell."
Hum Mol Genet18p2779-90(2009)
Johnson SL, Franz C, Knipper M, Marcotti W
"Functional maturation of the exocytotic machinery at gerbil hair cell ribbon synapses."
J Physiol587p1715-26(2009)
Knipper, M
"Hearing loss - the key healthcare issue in the communication sector...[external content]"
Public Service Review: Science and Technology - Issue 5 (2009)
Kuhn S, Knirsch M, Rüttiger L, Kasperek S, Winter H, Freichel M, Flockerzi V, Knipper M, Engel J
"Ba2+ currents in inner and outer hair cells of mice lacking the voltage-dependent Ca2+ channel subunits beta3 or beta4."
Channels (Austin)3p366-76(2009)
Winter H, Rüttiger L, Müller M, Kuhn S, Brandt N, Zimmermann U, Hirt B, Bress A, Sausbier M, Conscience A, Flamant F, Tian Y, Zuo J, Pfister M, Ruth P, Löwenheim H, Samarut J, Engel J, Knipper M
"Deafness in TRbeta mutants is caused by malformation of the tectorial membrane."
J Neurosci29p2581-7(2009)
Dlugaiczyk J, Singer W, Schick B, Iro H, Becker K, Becker CM, Zimmermann U, Rohbock K, Knipper M
"Expression of glycine receptors and gephyrin in the rat cochlea."
Histochem Cell Biol129p513-23(2008)
Friauf E, Wenz M, Oberhofer M, Nothwang HG, Balakrishnan V, Knipper M, Löhrke S
"Hypothyroidism impairs chloride homeostasis and onset of inhibitory neurotransmission in developing auditory brainstem and hippocampal neurons."
Eur J Neurosci28p2371-80(2008)
Heidrych P, Zimmermann U, Bress A, Pusch CM, Ruth P, Pfister M, Knipper M, Blin N
"Rab8b GTPase, a protein transport regulator, is an interacting partner of otoferlin, defective in a human autosomal recessive deafness form."
Hum Mol Genet17p3814-21(2008)
Hossain A, Hajman K, Charitidi K, Erhardt S, Zimmermann U, Knipper M, Canlon B
"Prenatal dexamethasone impairs behavior and the activation of the BDNF exon IV promoter in the paraventricular nucleus in adult offspring."
Endocrinology149p6356-65(2008)
Johnson SL, Forge A, Knipper M, Münkner S, Marcotti W
"Tonotopic variation in the calcium dependence of neurotransmitter release and vesicle pool replenishment at mammalian auditory ribbon synapses."
J Neurosci28p7670-8(2008)
König O, Rüttiger L, Müller M, Zimmermann U, Erdmann B, Kalbacher H, Gross M, Knipper M
"Estrogen and the inner ear: megalin knockout mice suffer progressive hearing loss."
FASEB J22p410-7(2008)
Lubka M, Müller M, Baus-Loncar M, Hinz M, Blaschke K, Hoffmann W, Pfister M, Löwenheim H, Pusch CM, Knipper M, Blin N
"Lack of Tff3 peptide results in hearing impairment and accelerated presbyacusis."
Cell Physiol Biochem21p437-44(2008)
Panford-Walsh R, Singer W, Rüttiger L, Hadjab S, Tan J, Geisler HS, Zimmermann U, Köpschall I, Rohbock K, Vieljans A, Oestreicher E, Knipper M
"Midazolam reverses salicylate-induced changes in brain-derived neurotrophic factor and arg3.1 expression: implications for tinnitus perception and auditory plasticity."
Mol Pharmacol74p595-604(2008)
Singer W, Panford-Walsh R, Watermann D, Hendrich O, Zimmermann U, Köpschall I, Rohbock K, Knipper M
"Salicylate alters the expression of calcium response transcription factor 1 in the cochlea: implications for brain-derived neurotrophic factor transcriptional regulation."
Mol Pharmacol73p1085-91(2008)
Alavi MV, Bette S, Schimpf S, Schuettauf F, Schraermeyer U, Wehrl HF, Ruttiger L, Beck SC, Tonagel F, Pichler BJ, Knipper M, Peters T, Laufs J, Wissinger B
"A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy."
Brain130p1029-42(2007)
Albert JT, Winter H, Schaechinger TJ, Weber T, Wang X, He DZ, Hendrich O, Geisler HS, Zimmermann U, Oelmann K, Knipper M, Göpfert MC, Oliver D
"Voltage-sensitive prestin orthologue expressed in zebrafish hair cells."
J Physiol580p451-61(2007)
Bette S, Zimmermann U, Wissinger B, Knipper M
"OPA1, the disease gene for optic atrophy type Kjer, is expressed in the inner ear."
Histochem Cell Biol128p421-30(2007)
Bichelmeier U, Schmidt T, Hübener J, Boy J, Rüttiger L, Häbig K, Poths S, Bonin M, Knipper M, Schmidt WJ, Wilbertz J, Wolburg H, Laccone F, Riess O
"Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence."
J Neurosci27p7418-28(2007)
Brandt N, Kuhn S, Münkner S, Braig C, Winter H, Blin N, Vonthein R, Knipper M, Engel J
"Thyroid hormone deficiency affects postnatal spiking activity and expression of Ca2+ and K+ channels in rodent inner hair cells."
J Neurosci27p3174-86(2007)
Knipper M
"[Therapeutic use of stem cells]."
HNO55p845-7(2007)
Knirsch M, Brandt N, Braig C, Kuhn S, Hirt B, Münkner S, Knipper M, Engel J
"Persistence of Ca(v)1.3 Ca2+ channels in mature outer hair cells supports outer hair cell afferent signaling."
J Neurosci27p6442-51(2007)
Lang F, Vallon V, Knipper M, Wangemann P
"Functional significance of channels and transporters expressed in the inner ear and kidney."
Am J Physiol Cell Physiol293pC1187-208(2007)
Rüttiger L, Panford-Walsh R, Schimmang T, Tan J, Zimmermann U, Rohbock K, Köpschall I, Limberger A, Müller M, Fraenzer JT, Cimerman J, Knipper M
"BDNF mRNA expression and protein localization are changed in age-related hearing loss."
Neurobiol Aging28p586-601(2007)
Tan J, Rüttiger L, Panford-Walsh R, Singer W, Schulze H, Kilian SB, Hadjab S, Zimmermann U, Köpschall I, Rohbock K, Knipper M
"Tinnitus behavior and hearing function correlate with the reciprocal expression patterns of BDNF and Arg3.1/arc in auditory neurons following acoustic trauma."
Neuroscience145p715-26(2007)
Winter H, Braig C, Zimmermann U, Engel J, Rohbock K, Knipper M
"Thyroid hormone receptor alpha1 is a critical regulator for the expression of ion channels during final differentiation of outer hair cells."
Histochem Cell Biol128p65-75(2007)
Engel J, Braig C, Rüttiger L, Kuhn S, Zimmermann U, Blin N, Sausbier M, Kalbacher H, Münkner S, Rohbock K, Ruth P, Winter H, Knipper M
"Two classes of outer hair cells along the tonotopic axis of the cochlea."
Neuroscience143p837-49(2006)
Knipper M, Claussen C, Rüttiger L, Zimmermann U, Lüllmann-Rauch R, Eskelinen EL, Schröder J, Schwake M, Saftig P
"Deafness in LIMP2-deficient mice due to early loss of the potassium channel KCNQ1/KCNE1 in marginal cells of the stria vascularis."
J Physiol576p73-86(2006)
Knipper M, Weber T, Winter H, Braig C, Cimerman J, Fraenzer JT, Zimmermann U
"Individual characteristics of members of the SLC26 family in vertebrates and their homologues in insects."
Novartis Found Symp273p19-30; discussion 30-41, 261-4(2006)
Schick B, Starlinger V, Haberle L, Eigenthaler M, Walter U, Knipper M
"Delayed formation of actin filaments in the outer pillar head plate of VASP-/- mice."
Cells Tissues Organs184p88-95(2006)
Schug N, Braig C, Zimmermann U, Engel J, Winter H, Ruth P, Blin N, Pfister M, Kalbacher H, Knipper M
"Differential expression of otoferlin in brain, vestibular system, immature and mature cochlea of the rat."
Eur J Neurosci24p3372-80(2006)
van Wijk E, van der Zwaag B, Peters T, Zimmermann U, Te Brinke H, Kersten FF, Märker T, Aller E, Hoefsloot LH, Cremers CW, Cremers FP, Wolfrum U, Knipper M, Roepman R, Kremer H
"The DFNB31 gene product whirlin connects to the Usher protein network in the cochlea and retina by direct association with USH2A and VLGR1."
Hum Mol Genet15p751-65(2006)
Winter H, Braig C, Zimmermann U, Geisler HS, Fränzer JT, Weber T, Ley M, Engel J, Knirsch M, Bauer K, Christ S, Walsh EJ, McGee J, Köpschall I, Rohbock K, Knipper M
"Thyroid hormone receptors TRalpha1 and TRbeta differentially regulate gene expression of Kcnq4 and prestin during final differentiation of outer hair cells."
J Cell Sci119p2975-84(2006)
Löwenheim H, Reichl J, Winter H, Hahn H, Simon C, Gültig K, Müller A, Zenner HP, Zimmermann U, Knipper M
"In vitro expansion of human nasoseptal chondrocytes reveals distinct expression profiles of G1 cell cycle inhibitors for replicative, quiescent, and senescent culture stages."
Tissue Eng11p64-75(2005)
Reiners J, van Wijk E, Märker T, Zimmermann U, Jürgens K, te Brinke H, Overlack N, Roepman R, Knipper M, Kremer H, Wolfrum U
"Scaffold protein harmonin (USH1C) provides molecular links between Usher syndrome type 1 and type 2."
Hum Mol Genet14p3933-43(2005)
Reisinger E, Zimmermann U, Knipper M, Ludwig J, Klöcker N, Fakler B, Oliver D
"Cod106, a novel synaptic protein expressed in sensory hair cells of the inner ear and in CNS neurons."
Mol Cell Neurosci28p106-17(2005)
Bildl W, Strassmaier T, Thurm H, Andersen J, Eble S, Oliver D, Knipper M, Mann M, Schulte U, Adelman JP, Fakler B
"Protein kinase CK2 is coassembled with small conductance Ca(2+)-activated K+ channels and regulates channel gating."
Neuron43p847-58(2004)
Carnicero E, Zelarayan LC, Rüttiger L, Knipper M, Alvarez Y, Alonso MT, Schimmang T
"Differential roles of fibroblast growth factor-2 during development and maintenance of auditory sensory epithelia."
J Neurosci Res77p787-97(2004)
Katz E, Elgoyhen AB, Gómez-Casati ME, Knipper M, Vetter DE, Fuchs PA, Glowatzki E
"Developmental regulation of nicotinic synapses on cochlear inner hair cells."
J Neurosci24p7814-20(2004)
Rüttiger L, Sausbier M, Zimmermann U, Winter H, Braig C, Engel J, Knirsch M, Arntz C, Langer P, Hirt B, Müller M, Köpschall I, Pfister M, Münkner S, Rohbock K, Pfaff I, Rüsch A, Ruth P, Knipper M
"Deletion of the Ca2+-activated potassium (BK) alpha-subunit but not the BKbeta1-subunit leads to progressive hearing loss."
Proc Natl Acad Sci U S A101p12922-7(2004)
Schick B, Praetorius M, Eigenthaler M, Jung V, Müller M, Walter U, Knipper M
"Increased noise sensitivity and altered inner ear MENA distribution in VASP-/- mice."
Cell Tissue Res318p493-502(2004)
Bartolami S, Augé C, Travo C, Ventéo S, Knipper M, Sans A
"Vestibular Schwann cells are a distinct subpopulation of peripheral glia with specific sensitivity to growth factors and extracellular matrix components."
J Neurobiol57p270-90(2003)
Oliver D, Knipper M, Derst C, Fakler B
"Resting potential and submembrane calcium concentration of inner hair cells in the isolated mouse cochlea are set by KCNQ-type potassium channels."
J Neurosci23p2141-9(2003)
Rüttiger L, Ciuffani J, Zenner HP, Knipper M
"A behavioral paradigm to judge acute sodium salicylate-induced sound experience in rats: a new approach for an animal model on tinnitus."
Hear Res180p39-50(2003)
Schick B, Praetorius M, Eigenthaler M, Mack A, Plinkert P, Walter U, Dazert S, Knipper M
"Expression of VASP and zyxin in cochlear pillar cells: indication for actin-based dynamics?"
Cell Tissue Res311p315-23(2003)
Schimmang T, Tan J, Müller M, Zimmermann U, Rohbock K, Kôpschall I, Limberger A, Minichiello L, Knipper M
"Lack of Bdnf and TrkB signalling in the postnatal cochlea leads to a spatial reshaping of innervation along the tonotopic axis and hearing loss."
Development130p4741-50(2003)
Waka N, Knipper M, Engel J
"Localization of the calcium channel subunits Cav1.2 (alpha1C) and Cav2.3 (alpha1E) in the mouse organ of Corti."
Histol Histopathol18p1115-23(2003)
Weber T, Gopfert MC, Winter H, Zimmermann U, Kohler H, Meier A, Hendrich O, Rohbock K, Robert D, Knipper M
"Expression of prestin-homologous solute carrier (SLC26) in auditory organs of nonmammalian vertebrates and insects."
Proc Natl Acad Sci U S A100p7690-5(2003)
Carnicero E, Knipper M, Tan J, Alonso MT, Schimmang T
"Herpes simplex virus type 1-mediated transfer of neurotrophin-3 stimulates survival of chicken auditory sensory neurons."
Neurosci Lett321p149-52(2002)
Postigo A, Calella AM, Fritzsch B, Knipper M, Katz D, Eilers A, Schimmang T, Lewin GR, Klein R, Minichiello L
"Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons."
Genes Dev16p633-45(2002)
Praetorius M, Knipper M, Schick B, Tan J, Limberger A, Carnicero E, Alonso MT, Schimmang T
"A novel vestibular approach for gene transfer into the inner ear."
Audiol Neurootol7p324-34(2002)
Weber T, Zimmermann U, Winter H, Mack A, Köpschall I, Rohbock K, Zenner HP, Knipper M
"Thyroid hormone is a critical determinant for the regulation of the cochlear motor protein prestin."
Proc Natl Acad Sci U S A99p2901-6(2002)
Knipper M, Richardson G, Mack A, Müller M, Goodyear R, Limberger A, Rohbock K, Köpschall I, Zenner HP, Zimmermann U
"Thyroid hormone-deficient period prior to the onset of hearing is associated with reduced levels of beta-tectorin protein in the tectorial membrane: implication for hearing loss."
J Biol Chem276p39046-52(2001)
Praetorius M, Limberger A, Müller M, Lehner R, Schick B, Zenner HP, Plinkert P, Knipper M
"A novel microperfusion system for the long-term local supply of drugs to the inner ear: implantation and function in the rat model."
Audiol Neurootol6p250-8(2001)
Knipper M, Zinn C, Maier H, Praetorius M, Rohbock K, Köpschall I, Zimmermann U
"Thyroid hormone deficiency before the onset of hearing causes irreversible damage to peripheral and central auditory systems."
J Neurophysiol83p3101-12(2000)
Oestreicher E, Knipper M, Arnold A, Zenner HP, Felix D
"Neurotrophin 3 potentiates glutamatergic responses of IHC afferents in the cochlea in vivo."
Eur J Neurosci12p1584-90(2000)
Zimmermann U, Köpschall I, Rohbock K, Bosman GJ, Zenner HP, Knipper M
"Molecular characterization of anion exchangers in the cochlea."
Mol Cell Biochem205p25-37(2000)
Gestwa G, Wiechers B, Zimmermann U, Praetorius M, Rohbock K, Köpschall I, Zenner HP, Knipper M
"Differential expression of trkB.T1 and trkB.T2, truncated trkC, and p75(NGFR) in the cochlea prior to hearing function."
J Comp Neurol414p33-49(1999)
Knipper M, Gestwa L, Ten Cate WJ, Lautermann J, Brugger H, Maier H, Zimmermann U, Rohbock K, Köpschall I, Wiechers B, Zenner HP
"Distinct thyroid hormone-dependent expression of TrKB and p75NGFR in nonneuronal cells during the critical TH-dependent period of the cochlea."
J Neurobiol38p338-56(1999)
Wiechers B, Gestwa G, Mack A, Carroll P, Zenner HP, Knipper M
"A changing pattern of brain-derived neurotrophic factor expression correlates with the rearrangement of fibers during cochlear development of rats and mice."
J Neurosci19p3033-42(1999)
Knipper M, Bandtlow C, Gestwa L, Köpschall I, Rohbock K, Wiechers B, Zenner HP, Zimmermann U
"Thyroid hormone affects Schwann cell and oligodendrocyte gene expression at the glial transition zone of the VIIIth nerve prior to cochlea function."
Development125p3709-18(1998)
Knipper M
"[NT-3 and BDNF for potential inner ear therapy]."
HNO45p181-3(1997)
Knipper M, Rylett RJ
"A new twist in an old story: the role for crosstalk of neuronal and trophic activity."
Neurochem Int31p659-76(1997)
Knipper M, Köpschall I, Rohbock K, Köpke AK, Bonk I, Zimmermann U, Zenner H
"Transient expression of NMDA receptors during rearrangement of AMPA-receptor-expressing fibers in the developing inner ear."
Cell Tissue Res287p23-41(1997)
Knipper M, Zimmermann U, Rohbock K, Köpschall I, Zenner HP
"Expression of neurotrophin receptor trkB in rat cochlear hair cells at time of rearrangement of innervation."
Cell Tissue Res283p339-53(1996)
Knipper M, Zimmermann U, Köpschall I, Rohbock K, Jüngling S, Zenner HP
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