Curriculum Vitae – Prof. Dr. med. Hubert Löwenheim
Current Position: Professor and Chair, Dept. of Otolaryngology - Head & Neck Surgery, University of Tübingen Medical Center
Current Institution:
Eberhard-Karls-Universität Tübingen (EKUT)
Dept of Otolaryngology, Head and Neck Surgery (OHNS)
Elfriede-Aulhorn-Str. 5, 72076 Tübingen, DE
ORCID: 0000-0001-8200-8804
Pubmed
Qualifications and Career
Degree:
1997: German Board of Otorhinolaryngology, State Chamber of Physicians, Stuttgart, DE
1995: Doctorate, Auditory Physiology, Supervisor: Prof. Klinke, University of Frankfurt, DE
1992-1997: Resident, University of Tübingen Medical School, DE
Stages of academic/professional carrer:
Since 2016: Professor and Chair Department Otolaryngology- Head & Neck Surgery, Tübingen University Medical center, DE
2014-2016: Professor and Chair, Department Otolaryngology- Head & Neck Surgery, Oldenburg University Medical School, DE
2009-2014: Assoc. Professor and Deputy Chair, Department Otolaryngology- Head & Neck Surgery, Tübingen University Medical center, DE
2006-2014: Consultant in Charge
2006: Habilitation Otorhinolaryngology, University of Tübingen, Prof. Dr. H.P. Zenner
1997-2009: Senior Physician (Oberarzt)
1998: Visiting Research Fellow - Virginia Merrill Boedell Hearing Research Center, University of Washington - Seattle, USA
1997: Visiting Researcher, Dept of Neuroscience and Communication, University of Keele, UK
1993: Visiting Researcher, Dept of Neuroscience, University of Virginia, Charlottesville, USA
1992-1997: Internship/Assistant Doctor, Department Otolaryngology- Head & Neck Surgery, Tübingen University Medical Center, DE
Activities in the Research System
Clinical studies:
Main investigator: BEMED - Double-blind, placebo-controlled clinical trial “Therapy of Menière's disease with betahistine” (DSGZ, German Dizziness and Balance Center)
Main investigator: Application observation “Vibroplasty Couplers” (Sponsor: Vibrant MedEl, Innsbruck, Austria)
Main investigator: BETAVEST - double-blind, placebo-controlled clinical trial “Effects of betahistine on central vestibular compensation in acute unilateral vestibulopathy” (DSGZ, German Dizziness and Balance Center)
Main investigator: PROVEMIG - double-blind, placebo-controlled clinical trial “Prophylactic treatment of vestibular migraine with metoprolol” (DSGZ, German Dizziness and Balance Center)
10 selected publications
Tropitzsch A, Schade-Mann T, Gamerdinger P, Dofek S, Schulte B, Schulze M, Fehr S, Biskup S, Haack TB, Stöbe P, Heyd A, Jennifer Harre J, Lesinski-Schiedat A, Büchner A, Lenarz T, Warnecke A, Müller M, Vona B, Dalhoff E,
Löwenheim H, Holderried M
(2023) Variability in Cochlear Implantation Outcomes in a Large German Cohort with a Genetic Etiology of Hearing Loss.
Ear Hear. 44(6):1464-1484
DOI:10.1097/AUD.0000000000001386 (conceptualization, recruitment of the families, data curation, clinical data interpretation, writing)
Guntinas-Lichius O, Arnold D, Volk GF, Korth D, Aschenbach R, Hempel JM, Schneider F, Schade-Mann T, Gamerdinger P, Tropitzsch A,
Löwenheim H (2022) Accessing the stapedius muscle via novel surgical retrofacial approach during cochlear implantation surgery: Intraoperative results on feasibility and safety.
PLoS One. 17(8):e0272943.
DOI: 10.1371/journal.pone.0272943 Open Access
(conceptualization, project administration, resources, validation, writing – review & editing)
Peixoto Pinheiro B, Müller M, Bös M, Guezguez J, Burnet M, Tornincasa M, Rizzetto R, Rolland JF, Liberati C, Lohmer S, Adel Y,
Löwenheim H (2022) A potassium channel agonist protects hearing function and promotes outer hair cell survival in a mouse model for age-related hearing loss.
Cell Death Dis. 13(7):595.
DOI:10.1038/s41419-022-04915-5 Open Access
(conceptualization, supervision, interpretation, writing)
Trpchevska N, (> 30 authors…),
Löwenheim H, (>20 authors…), Cederroth CR, Williams FMK, Nagtegaal AP
(2022) Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss.
Am J Hum Genet. 109(6):1077-1091.
DOI:10.1016/j.ajhg.2022.04.010 Open Access
(contributed to cohort-specific data collection, analysis)
Tropitzsch A, Schade-Mann T, Gamerdinger P, Dofek S, Schulte B, Schulze M, Battke F, Fehr S, Biskup S, Heyd A, Müller M,
Löwenheim H, Vona B, Holderried M
(2022) Diagnostic yield of targeted hearing loss gene panel sequencing in a large german cohort with a balanced age distribution from a single diagnostic center: an eight-year study.
Ear Hear. 43(3):1049-1066.
DOI:10.1097/AUD.0000000000001159 (contributed to the sutdy conception, recruitment of the failies, data curation, clinical data interpretation, writing)
Peixoto Pinheiro B, Adel Y, Knipper M, Müller M,
Löwenheim H (2021) Auditory Threshold Variability in the SAMP8 Mouse Model of Age-Related Hearing Loss: Functional Loss and Phenotypic Change Precede Outer Hair Cell Loss.
Front Aging Neurosci. 13:708190.
DOI: 10.3389/fnagi.2021.708190 Open Access
(conceptualization, supervision, interpretation, writing)
Rousset F, Kokje VBC, Sipione R, Schmidbauer D, Nacher-Soler G, Ilmjärv S, Coelho M, Fink S, Voruz F, El Chemaly A, Marteyn A, *Löwenheim H*, Krause KH, Müller M, Glückert R, Senn P
(2020) Intrinsically self-renewing neuroprogenitors from the A/J mouse spiral ganglion as virtually unlimited source of mature auditory neurons.
Front Cell Neurosci. 14:395.
DOI:10.3389/fncel.2020.599152 Open Access
(funding acquisition, writing)
Rad A, Schade-Mann T, Gamerdinger P, Yanus GA, Schulte B, Müller M, Imyanitov EN, Biskup S,
Löwenheim H, Tropitzsch A, Vona B
(2021) Aberrant COL11A1 splicing causes prelingual autosomal dominant nonsyndromic hearing loss in the DFNA37 locus.
Hum Mutat. 42(1):25-30.
DOI:10.1002/humu.24136 Open Access
(study conception, recruitment of the families, data curation and clinical data interpretation)
Braun K, Walker K, Sürth W,
Löwenheim H, Tropitzsch A
(2019) Triphasic pulses in cochlear implant patients with facial nerve stimulation.
Otol Neurotol. 40(10):1268-1277.
DOI: 10.1097/MAO.0000000000002398 (study conception, clinical data interpretation, writing)
Kramer B, Tropitzsch A, Müller M,
Löwenheim H (2017) Myelin-induced inhibition in a spiral ganglion organ culture - Approaching a natural environment in vitro.
Neuroscience. 357: 75-83.
DOI:10.1016/j.neuroscience.2017.05.053 (study design, writing)