Curriculum Vitae – Associate Prof. Dr. Christopher R. Cederroth
General information
Current Position: Senior Scientist
Current Institution:
Eberhard-Karls-Universität Tübingen (EKUT)
Dept of Otolaryngology, Head and Neck Surgery (OHNS)
Molecular Physiology of Hearing
Elfriede-Aulhorn-Str. 5, 72076 Tübingen, DE
ORCID: 0000-0001-7267-5136
Qualifications and Career
Degree:
2004-2005: Licenciate degree, University of Geneva, CH
2009: Doctorate, Medical Biology, Supervisors: Prof. Serge Nef, Prof. Jean-Dominique Vassalli, Prof. Ivan Rodriguez, GEDEV Dpt., University of Geneva Medical Centre, CH
Stages of academic/professional carrer:
Since 2023 : Senior scientist, OHNS Department, Tübingen, DE
2021-2023 : Scientific Officer, Swiss 3R Competence Centre, Bern, CH
2021-2023 : Honorary Associate Professor, NIHR Bioscience Research Centre, Nottingham, UK
2020-2021 : Associate Professor, NIHR Bioscience Research Centre, Nottingham, UK
Since 2018 : Associate Professor, Dpt. of Physiology and Pharmacology, Karolinska Institutet, Stockholm, SE
Since 2015 : Group leader, Laboratory of Translational Auditory Neuroscience, Karolinska Institutet, Stockholm, SE
2015-2018 : Assistant Professor, Dpt. of Physiology and Pharmacology, Karolinska Institutet, Stockholm, SE
2012-2014 : Post-Doctoral Fellow, Dpt. of Physiology and Pharmacology, Karolinska Institutet, Stockholm, SE
2009-2012 : Post-Doctoral Fellow, Dpt. of Sensory Neuroscience, HHMI and The Rockefeller University, New York, USA
Activities in the Research System
Reviewer for Funding Agencies
including: Swiss National Science Foundation (CH), Action for Hearing Loss (UK), RNID (UK), American Tinnitus Asociation (USA), Fondation pour l’Audition (FR), European Social Fund (BE), ZONMW (ZorgOnderzoek, NL), KI Doctoral Grants (SWE).
Reviewer for Scientific Journals
including: Hear Res, Frontiers, PloS One, Sci Rep, JAMA Otol, Health and Longevity, Physiology Reviews, JAMA Neurology, Cerebral Cortex, Nitric Oxice, Neurotoxicology, B J Nutr, Int J Obes, J Appl Physiol, J Endocrinol.
Teaching
Since 2021 : Lecturer on the neurophysiology of senses for the 2nd-year Medical students (20 h/year)
Since 2018 : Lecturer on the neurophysiology of senses for the open courses on Human Physiology
Since 2018 : Lecturer on the neurophysiology of senses for the 2nd-year Dental students (20 h/year)
Since 2012 : Auditory and Vestibular laboratories for medical and dental students (32h/year)
Other
2023 Co-Organizer “3Rs Day 2022”, Annual Meeting from the Swiss 3R Competence Center, Bern, CH
Academic Distinctions
Since 2021: Editor-in-Chief, Journal of the Association for Research in Otolaryngology, USA (JARO)
2020 : Geraldine Dietz Fox Young Investigator Award from ARO
2020 : Member of the animal welfare committee of the Region Stockholm, Sweden
Since 2020 : Professional’s Advisers’ Committee member, British Tinnitus Association, UK
Since 2019 : Scientific Advisory Board member, American Tinnitus Association, USA
Since 2019 : Scientific Collaborator, Global Burden of Disease Study, US
2019 : Research Prize in Tinnitus and Hearing 2020 – Deutsche Stiftung für Tinnitus und Hören Charité, DE
2014 : Excellence in reviewing in the journal Hearing Research
2013 : Most highly cited publication in Molecular and Cellular Endocrinology since 2009
2011 : Philippe Foundation Prize, USA
2010 : Denber-Pinard Prize, CH
2007 : Endocrinology Foundation Prize, CH
Selected publications
- Mathiesen BK, Miyakoshi LM, Cederroth CR,Tserga E, Versteegh CPC, Bork PAR, Hauglund NL, Gomolka RS, Mori Y, Edvall NK, Rouse S, Møllgård K, Holt JR, Nedergaard M, Canlon B (2023) Delivery of gene therapy through a cerebrospinal fluid conduit to rescue hearing. Sci Transl Med. 15(702):eabq3916. DOI:10.1126/scitranslmed.abq3916 Open Access
(conceptualization, formal analysis, funding acquisition, methodology, project administration, supervision, validation, visualization, writing - original draft, writing - review & editing)
- Jarach CM, Lugo A, Scala M, van den Brandt PA, Cederroth CR, Odone A, Garavello W, Schlee W, Langguth B, Gallus S (2022) Global Prevalence and Incidence of Tinnitus: A Systematic Review and Meta-analysis. JAMA Neurol. e222189. DOI:10.1001/jamaneurol.2022.2189 Open Access
(conceptualization, design, critical revision, obtained funding)
- Trpchevska N, Freidin M, Broer L, Oosterloo BC, Yao S, Zhou Y, Vona B, Bishop C, Bizaki-Vallaskangas A, Canlon B, Castellana F, Chasman D, Cherny S, Christensen K, Pina Concas M, Correa A, Elkon R, Estonian Biobank Research Team, Mengel-From J, Gao Y, Giersch ABS, Girotto G, Gudjonsson A, Gudnason V, Heard-Costa NL, Hertzano R, v. B. Hjelmborg J, Hjerling-Leffler J, Hoffman HJ, Kaprio J, Kettunen J, Krebs K, Kähler AK, Lallemend F, Launer LJ, Lee I, Leonard H, Li CM, Lowenheim H, Magnusson PKE, van Meurs J, Milani L, Morton CC, Mäkitie A, Nalls MA, Giovanni Nardone G, Nygaard M, Palviainen T, Pratt S, Quaranta N, Rämö J, Saarentaus E, Sardone R, Satizabal Barrera CL, Schweinfurth JM, Seshadri S, Shiroma E, Shulman E, Simonsick E, Spankovich C, Tropitzsch A, Lauschke VM, Sullivan PF, Goedegebure A, Cederroth CR, Williams FMK, Nagtegaal AP (2022) Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in age-related hearing impairment. Am J Hum Genet. 109(6):1077-1091. DOI:10.1016/j.ajhg.2022.04.010 Open Access
(conceptualization, research design, writing, editing, overseeing project)
- Edvall NK, Mehraei G, Claeson M, Bulla J, Lazar A, Uhlen I, Schlee W, Leineweber C, Canlon B, Cederroth CR (2022) Alterations in auditory brainstem response as an electrophysiological biomarker that distinguishes occasional and constant tinnitus. J Clin Invest. 132(5):e155094. DOI:10.1172/JCI155094 Open Access
(research design, discussion, writing)
- Milon B, Shulman ED, So KS, Cederroth CR, Lipford EL, Sperber M, Sellon JB, Sarlus H, Pregernig G, Shuster B, Song Y, Mitra S, Orvis J, Margulies Z, Ogawa Y, Shults C, Depireux DA, Palermo AT, Canlon B, Burns J, Elkon R, Hertzano R (2021) A cell-type-specific atlas of the inner ear transcriptional response to acoustic trauma. Cell Rep. 36(13):109758. DOI:10.1016/j.celrep.2021.109758 Open Access
(conceptualization, writing, editing, supervision)
- Amanat S, Gallego-Martinez A, Sollini J, Perez-Carpena P, Espinosa-Sanchez JM, Aran I, Soto-Varela A, Batuecas-Caletrio A, Canlon B, May P, Cederroth CR, Lopez-Escamez JA (2021) Burden of rare variants in synaptic genes in patients with severe tinnitus: An exome based extreme phenotype study. EBioMedicine. 66:103309. DOI:10.1016/j.ebiom.2021.103309 Open Access
(data collection for STOP cohort)
- GBD 2019 Hearing Loss Collaborators (2021) Hearing loss prevalence and years lived with disability, 1990-2019: findings from the Global Burden of Disease Study 2019. Lancet. 397(10278):996-1009. DOI:10.1016/S0140-6736(21)00516-X Open Access
(contributed to providing critical feedback on methods or results, drafting the work)
- Cederroth CR, Park JS, Basinou B, Weger B, Kadri N, Magnusson AM, Gachon F and Canlon B (2019) Circadian regulation of cochlear sensitivity to noise via circulating glucocorticoids”. Curr Biol. 29(15):2477-2487.e6. DOI:10.1016/j.cub.2019.06.057 Open Access
(ex- and in-vivo experiments, data and statistical analysis, conception, writing of the manuscript)
- Cederroth CR, PirouziFard M, Trpchevska N, Idrizbegovic E, Canlon B, Sundqvist J, Sundqvist K, Zöller B (2019) Association of Genetic and Environmental Factors in Swedish Adoptees with Clinically Significant Tinnitus. JAMA Otolaryngol Head Neck Surg. 145(3):222-229. DOI:10.1001/jamaoto.2018.3852 Open Access
(concept, design, acquisition, analysis, interpretation, writing-drafting, funding, supervision)
- Maas IL, Brüggemann P, Requena Navarro T, Bulla J, Edvall NK, Szczepek AJ, Canlon B, Mazurek B, Lopez-Escamez JA and Cederroth CR (2017) Genetic susceptibility to bilateral tinnitus in a Swedish twin cohort. Genet Med. 19(9):1007-12. DOI:10.1038/gim.2017.4 Open Access
(concept, design, acquisition, analysis, interpretation, writing, funding, supervision)
Patent:
Nedergaard M, Canlon B, Cederroth CR, Kock B: pending patent application for delivery of therapeutics to the inner ear via the cisterna magna (International Patent Application No. PCT/US22/82226, title: “Compositions and methods for delivery of agents to the inner ear”).
