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Molecular Physiology of Hearing

Prof. Dr. Marlies Knipper

Department of Otolaryngology, Head and Neck Surgery
Tübingen Hearing Research Centre
Elfriede-Aulhorn-Strasse 5
D-72076 Tübingen
Germany

Phone: +49 (0)7071 - 29 88244
Fax: +49 (0)7071 - 29 4950
marlies.knipper@uni-tuebingen.de

Research Interest

Our primary research focuses on the critical period of inner ear development prior to cochlear functioning and its influences on mature auditory processing in the healthy and diseased organ. Of particular interest are differential central auditory responsiveness to auditory deprivation post acoustic trauma. We specialized in this context on defining functional and molecular biomarkers for age-dependent hearing loss, tinnitus and hyperacusis using ABR responses, electrophysiological approaches, field potential measurements, behavior animal models, transgenic mice techniques.

Research Scientists

Molecular Neurobiology


Monika Gaus, administration
Phone: +49 (0) 7071 - 29 88243


Kerstin Just, administration
Phone: +49 (0) 7071 - 29 88242


Dr. Wibke Singer, research scientist
Phone: +49 (0)7071 - 29 88246


Hyun-Soon Geisler, Technician
Phone: +49 (0)7071 - 29 88268


Iris Köpschall, Technician
Phone: +49 (0)7071 - 29 88245


Karin Rohbock, Technician
Phone: +49 (0)7071 - 29 88245


Philipp Armbruster, PhD student
Phone: +49 (0)7071 - 29 88240


Kamyar Kasini, PhD student
Phone: +49 (0)7071 - 29 88240


Moritz Walter, PhD student
Phone: +49 (0)7071 - 29 88240


Benedikt Hofmeier
Phone: +49 (0)7071 - 29 88240


Philipp Eckert
Phone: +49 (0)7071 - 29 88240

Electrophysiology


PD Dr. Lukas Rüttiger (Head of Lab)
Phone: +49 (0)7071 - 29 88260


Dorit Moehrle, PhD student
Phone: +49 (0)7071 - 29 88184


Marie Manthey, PhD student
Phone: +49 (0)7071 - 29 88195


Steffen Wolter, PhD student
Phone: +49 (0)7071 - 29 88240

Publications

2018

Matt L, Eckert P, Panford-Walsh R, Geisler HS, Bausch AE, Manthey M, Müller NIC, Harasztosi C, Rohbock K, Ruth P, Friauf E, Ott T, Zimmermann U, Rüttiger L, Schimmang T, Knipper M, Singer W
"Visualizing BDNF Transcript Usage During Sound-Induced Memory Linked Plasticity."
Front Mol Neurosci11p260(2018)
Aazh H, Knipper M, Danesh AA, Cavanna AE, Andersson L, Paulin J, Schecklmann M, Heinonen-Guzejev M, Moore BCJ
"Insights from the third international conference on hyperacusis: causes, evaluation, diagnosis, and treatment."
Noise Health20p162-170(2018)
Singer W, Kasini K, Manthey M, Eckert P, Armbruster P, Vogt MA, Jaumann M, Dotta M, Yamahara K, Harasztosi C, Zimmermann U, Knipper M, Rüttiger L
"The glucocorticoid antagonist mifepristone attenuates sound-induced long-term deficits in auditory nerve response and central auditory processing in female rats."
FASEB Jpfj201701041RRR(2018)
Beer-Hammer S, Lee SC, Mauriac SA, Leiss V, Groh IAM, Novakovic A, Piekorz RP, Bucher K, Chen C, Ni K, Singer W, Harasztosi C, Schimmang T, Zimmermann U, Pfeffer K, Birnbaumer L, Forge A, Montcouquiol M, Knipper M, Nürnberg B, Rüttiger L
"Gαi Proteins are Indispensable for Hearing."
Cell Physiol Biochem47p1509-1532(2018)

2017

Neuhaus C, Lang-Roth R, Zimmermann U, Heller R, Eisenberger T, Weikert M, Markus S, Knipper M, Bolz HJ
"Extension of the clinical and molecular phenotype of DIAPH1-associated autosomal dominant hearing loss (DFNA1)."
Clin Genetp(2016)
Möhrle D, Reimann K, Wolter S, Wolters M, Varakina K, Mergia E, Eichert N, Geisler HS, Sandner P, Ruth P, Friebe A, Feil R, Zimmermann U, Koesling D, Knipper M, Rüttiger L
"NO-Sensitive Guanylate Cyclase Isoforms NO-GC1 and NO-GC2 Contribute to Noise-Induced Inner Hair Cell Synaptopathy."
Mol Pharmacol92p375-388(2017)
Mauriac SA, Hien YE, Bird JE, Carvalho SD, Peyroutou R, Lee SC, Moreau MM, Blanc JM, Geyser A, Medina C, Thoumine O, Beer-Hammer S, Friedman TB, Rüttiger L, Forge A, Nürnberg B, Sans N, Montcouquiol M
"Defective Gpsm2/Gα<sub>i3</sub> signalling disrupts stereocilia development and growth cone actin dynamics in Chudley-McCullough syndrome."
Nat Commun8p14907(2017)
Rüttiger L, Zimmermann U, Knipper M
"Biomarkers for Hearing Dysfunction: Facts and Outlook."
ORL J Otorhinolaryngol Relat Spec79p93-111(2017)

2016

Neuhaus C, Lang-Roth R, Zimmermann U, Heller R, Eisenberger T, Weikert M, Markus S, Knipper M, Bolz HJ
"Extension of the clinical and molecular phenotype of DIAPH1-associated autosomal dominant hearing loss (DFNA1)."
Clin Genetp(2016)
Lopez-Escamez JA, Bibas T, Cima RF, Van de Heyning P, Knipper M, Mazurek B, Szczepek AJ, Cederroth CR
"Genetics of Tinnitus: An Emerging Area for Molecular Diagnosis and Drug Development."
Front Neurosci10p377(2016)
Möhrle D, Ni K, Varakina K, Bing D, Lee SC, Zimmermann U, Knipper M, Rüttiger L
"Loss of auditory sensitivity from inner hair cell synaptopathy can be centrally compensated in the young but not old brain."
Neurobiol Aging44p173-84(2016)
Singer W, Geisler HS, Panford-Walsh R, Knipper M
"Detection of Excitatory and Inhibitory Synapses in the Auditory System Using Fluorescence Immunohistochemistry and High-Resolution Fluorescence Microscopy."
Methods Mol Biol1427p263-76(2016)
Dlugaiczyk J, Hecker D, Neubert C, Buerbank S, Campanelli D, Becker CM, Betz H, Knipper M, Rüttiger L, Schick B
"Loss of glycine receptors containing the α3 subunit compromises auditory nerve activity, but not outer hair cell function."
Hear Resp(2016)
Chumak T, Rüttiger L, Lee SC, Campanelli D, Zuccotti A, Singer W, Popelář J, Gutsche K, Geisler HS, Schraven SP, Jaumann M, Panford-Walsh R, Hu J, Schimmang T, Zimmermann U, Syka J, Knipper M
"BDNF in Lower Brain Parts Modifies Auditory Fiber Activity to Gain Fidelity but Increases the Risk for Generation of Central Noise After Injury."
Mol Neurobiolp(2015)
Reuss S, Closhen C, Riemann R, Jaumann M, Knipper M, Rüttiger L, Wolpert S
"Absence of Early Neuronal Death in the Olivocochlear System Following Acoustic Overstimulation."
Anat Rec (Hoboken)p(2015)

2015

Knipper M, Zimmermann U
"Über Hörstörungen, Stress und Emotionen. Wie unser Ohr Gehirnfunktionen beeinflusst."
Nova Acta Leopoldina NF, 122. 410: 63-81 (2015)
Ebbers L, Satheesh SV, Janz K, Rüttiger L, Blosa M, Hofmann F, Morawski M, Griesemer D, Knipper M, Friauf E, Nothwang HG
"L-type Calcium Channel Cav1.2 Is Required for Maintenance of Auditory Brainstem Nuclei."
J Biol Chem290p23692-710(2015)
Fritzsch B, Knipper M, Friauf E
"Auditory system: development, genetics, function, aging, and diseases."
Cell Tissue Resp(2015)
Schubert T, Gleiser C, Heiduschka P, Franz C, Nagel-Wolfrum K, Sahaboglu A, Weisschuh N, Eske G, Rohbock K, Rieger N, Paquet-Durand F, Wissinger B, Wolfrum U, Hirt B, Singer W, Rüttiger L, Zimmermann U, Knipper M
"Deletion of myosin VI causes slow retinal optic neuropathy and age-related macular degeneration (AMD)-relevant retinal phenotype."
Cell Mol Life Scip(2015)
Bing D, Lee SC, Campanelli D, Xiong H, Matsumoto M, Panford-Walsh R, Wolpert S, Praetorius M, Zimmermann U, Chu H, Knipper M, Rüttiger L, Singer W
"Cochlear NMDA Receptors as a Therapeutic Target of Noise-Induced Tinnitus."
Cell Physiol Biochem35p1905-1923(2015)
Knipper M, Panford-Walsh R, Singer W, Rüttiger L, Zimmermann U
"Specific synaptopathies diversify brain responses and hearing disorders: you lose the gain from early life."
Cell Tissue Resp(2015)
Thoenes M, Zimmermann U, Ebermann I, Ptok M, Lewis MA, Thiele H, Morlot S, Hess MM, Gal A, Eisenberger T, Bergmann C, Nürnberg G, Nürnberg P, Steel KP, Knipper M, Bolz H
"OSBPL2 encodes a protein of inner and outer hair cell stereocilia and is mutated in autosomal dominant hearing loss (DFNA67)."
Orphanet J Rare Dis10p15(2015)

2014

Chen JT, Guo D, Campanelli D, Frattini F, Mayer F, Zhou L, Kuner R, Heppenstall PA, Knipper M, Hu J
"Presynaptic GABAergic inhibition regulated by BDNF contributes to neuropathic pain induction."
Nat Commun5p5331(2014)
Knipper M
"Introduction to "compensation after injury: always for good?"."
Neuroscience283p1-3(2014)
Pirone A, Kurt S, Zuccotti A, Rüttiger L, Pilz P, Brown DH, Franz C, Schweizer M, Rust MB, Rübsamen R, Friauf E, Knipper M, Engel J
"α2δ3 Is Essential for Normal Structure and Function of Auditory Nerve Synapses and Is a Novel Candidate for Auditory Processing Disorders."
J Neurosci34p434-45(2014)
Schimmang T, Durán Alonso B, Zimmermann U, Knipper M
"Is there a relationship between brain-derived neurotrophic factor for driving neuronal auditory circuits with onset of auditory function and the changes following cochlear injury or during aging?"
Neuroscience283Cp26-43(2014)
Zampini V, Johnson SL, Franz C, Knipper M, Holley MC, Magistretti J, Russo G, Marcotti W, Masetto S
"Fine Tuning of CaV1.3 Ca2+ Channel Properties in Adult Inner Hair Cells Positioned in the Most Sensitive Region of the Gerbil Cochlea."
PLoS One9pe113750(2014)

2013

Cimerman J, Waldhaus J, Harasztosi C, Duncker SV, Dettling J, Heidrych P, Bress A, Gampe-Braig C, Frank G, Gummer AW, Oliver D, Knipper M, Zimmermann U
"Generation of somatic electromechanical force by outer hair cells may be influenced by prestin-CASK interaction at the basal junction with the Deiter's cell."
Histochem Cell Biolp(2013)
Duncker SV, Franz C, Kuhn S, Schulte U, Campanelli D, Brandt N, Hirt B, Fakler B, Blin N, Ruth P, Engel J, Marcotti W, Zimmermann U, Knipper M
"Otoferlin Couples to Clathrin-Mediated Endocytosis in Mature Cochlear Inner Hair Cells."
J Neurosci33p9508-9519(2013)
Dettling J, Franz C, Zimmermann U, Lee SC, Bress A, Brandt N, Feil R, Pfister M, Engel J, Flamant F, Rüttiger L, Knipper M
"Autonomous functions of murine thyroid hormone receptor TRα and TRβ in cochlear hair cells."
Mol Cell Endocrinolp(2013)
Furness DN, Johnson SL, Manor U, Rüttiger L, Tocchetti A, Offenhauser N, Olt J, Goodyear RJ, Vijayakumar S, Dai Y, Hackney CM, Franz C, Di Fiore PP, Masetto S, Jones SM, Knipper M, Holley MC, Richardson GP, Kachar B, Marcotti W
"Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2."
Proc Natl Acad Sci U S A110p13898-903(2013)
Knipper M, Van Dijk P, Nunes I, Rüttiger L, Zimmermann U
"Advances in the neurobiology of hearing disorders: Recent developments regarding the basis of tinnitus and hyperacusis."
Prog Neurobiolp(2013)
Johnson SL, Kuhn S, Franz C, Ingham N, Furness DN, Knipper M, Steel KP, Adelman JP, Holley MC, Marcotti W
"Presynaptic maturation in auditory hair cells requires a critical period of sensory-independent spiking activity."
Proc Natl Acad Sci U S Ap(2013)
Rüttiger L, Singer W, Panford-Walsh R, Matsumoto M, Lee SC, Zuccotti A, Zimmermann U, Jaumann M, Rohbock K, Xiong H, Knipper M
"The reduced cochlear output and the failure to adapt the central auditory response causes tinnitus in noise exposed rats."
PLoS One8pe57247(2013)
Singer W, Panford-Walsh R, Knipper M
"The function of BDNF in the adult auditory system."
Neuropharmacologyp(2013)
Singer W, Geisler HS, Knipper M
"The Geisler Method: Tracing Activity-Dependent cGMP Plasticity Changes upon Double Detection of mRNA and Protein on Brain Slices."
Methods Mol Biol1020p223-33(2013)
Singer W, Zuccotti A, Jaumann M, Lee SC, Panford-Walsh R, Xiong H, Zimmermann U, Franz C, Geisler HS, Köpschall I, Rohbock K, Varakina K, Verpoorten S, Reinbothe T, Schimmang T, Rüttiger L, Knipper M
"Noise-induced inner hair cell ribbon loss disturbs central arc mobilization: a novel molecular paradigm for understanding tinnitus."
Mol Neurobiol47p261-79(2013)
Zampini V, Johnson SL, Franz C, Knipper M, Holley MC, Magistretti J, Masetto S, Marcotti W
"Burst activity and ultrafast activation kinetics of CaV1.3 Ca2+ channels support presynaptic activity in adult gerbil hair cell ribbon synapses."
J Physiolp(2013)
Zuccotti A, Lee SC, Campanelli D, Singer W, Satheesh SV, Patriarchi T, Geisler HS, Köpschall I, Rohbock K, Nothwang HG, Hu J, Hell JW, Schimmang T, Rüttiger L, Knipper M
"L-type CaV1.2 deletion in the cochlea but not in the brainstem reduces noise vulnerability: implication for CaV1.2-mediated control of cochlear BDNF expression."
Front Mol Neurosci6p20(2013)

2012

Eckrich T, Varakina K, Johnson SL, Franz C, Singer W, Kuhn S, Knipper M, Holley MC, Marcotti W
"Development and function of the voltage-gated sodium current in immature mammalian cochlear inner hair cells."
PLoS One7pe45732(2012)
Föller M, Jaumann M, Dettling J, Saxena A, Pakladok T, Munoz C, Ruth P, Sopjani M, Seebohm G, Rüttiger L, Knipper M, Lang F
"AMP-activated protein kinase in BK-channel regulation and protection against hearing loss following acoustic overstimulation."
FASEB Jp(2012)
Jaumann M, Dettling J, Gubelt M, Zimmermann U, Gerling A, Paquet-Durand F, Feil S, Wolpert S, Franz C, Varakina K, Xiong H, Brandt N, Kuhn S, Geisler HS, Rohbock K, Ruth P, Schlossmann J, Hütter J, Sandner P, Feil R, Engel J, Knipper M, Rüttiger L
"cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function."
Nat Medp(2012)
Kammerer R, Ruettiger L, Riesenberg R, Schaeuble C, Krupar R, Kamp A, Sunami K, Eisenried A, Hennenberg M, Grunert F, Bress A, Battaglia S, Schrewe H, Knipper M, Schneider MR, Zimmermann W
"Loss of the mammal-specific tectorial membrane component CEA cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies."
J Biol Chemp(2012)
Knipper M, Müller M, Zimmermann U
"Molecular Mechanism of Tinnitus."
In: Springer Handbook of Audidory Research: TINNITUS (Eggermont JJ, Zeng F-G, Popper AN, Fay RR, eds). Springer New York Heidelberg, Dordrecht London, pp. 59-82. (2012)
Kurt S, Sausbier M, Rüttiger L, Brandt N, Moeller CK, Kindler J, Sausbier U, Zimmermann U, van Straaten H, Neuhuber W, Engel J, Knipper M, Ruth P, Schulze H
"Critical role for cochlear hair cell BK channels for coding the temporal structure and dynamic range of auditory information for central auditory processing."
FASEB Jp(2012)
Schraven SP, Franz C, Rüttiger L, Löwenheim H, Lysakowski A, Stoffel W, Knipper M
"Altered Phenotype of the Vestibular Organ in GLAST-1 Null Mice."
J Assoc Res Otolaryngol13p323-33(2012)
Satheesh SV, Kunert K, Rüttiger L, Zuccotti A, Schönig K, Friauf E, Knipper M, Bartsch D, Nothwang HG
"Retrocochlear function of the peripheral deafness gene Cacna1d."
Hum Mol Genetp(2012)
Zuccotti A, Kuhn S, Johnson SL, Franz C, Singer W, Hecker D, Geisler HS, Köpschall I, Rohbock K, Gutsche K, Dlugaiczyk J, Schick B, Marcotti W, Rüttiger L, Schimmang T, Knipper M
"Lack of Brain-Derived Neurotrophic Factor Hampers Inner Hair Cell Synapse Physiology, But Protects against Noise-Induced Hearing Loss."
J Neurosci32p8545-8553(2012)
Zak M, Breß A, Brandt N, Franz C, Ruth P, Pfister M, Knipper M, Blin N
"Ergic2, a brain specific interacting partner of otoferlin."
Cell Physiol Biochem29p941-8(2012)

2011

Buerbank S, Becker K, Becker CM, Brandt N, Engel J, Knipper M, Schick B, Dlugaiczyk J
"Developmental regulation of glycine receptors at efferent synapses of the murine cochlea."
Histochem Cell Biolp(2011)
Johnson SL, Eckrich T, Kuhn S, Zampini V, Franz C, Ranatunga KM, Roberts TP, Masetto S, Knipper M, Kros CJ, Marcotti W
"Position-dependent patterning of spontaneous action potentials in immature cochlear inner hair cells."
Nat Neurosci14p711-7(2011)
Zampini V, Rüttiger L, Johnson SL, Franz C, Furness DN, Waldhaus J, Xiong H, Hackney CM, Holley MC, Offenhauser N, Di Fiore PP, Knipper M, Masetto S, Marcotti W
"Eps8 regulates hair bundle length and functional maturation of Mammalian auditory hair cells."
PLoS Biol9pe1001048(2011)

2010

Gebhart M, Juhasz-Vedres G, Zuccotti A, Brandt N, Engel J, Trockenbacher A, Kaur G, Obermair GJ, Knipper M, Koschak A, Striessnig J
"Modulation of Cav1.3 Ca2+ channel gating by Rab3 interacting molecule."
Mol Cell Neurosci44p246-59(2010)
Johnson SL, Franz C, Kuhn S, Furness DN, Rüttiger L, Münkner S, Rivolta MN, Seward EP, Herschman HR, Engel J, Knipper M, Marcotti W
"Synaptotagmin IV determines the linear Ca2+ dependence of vesicle fusion at auditory ribbon synapses."
Nat Neurosci13p45-52(2010)
Knipper M, Zimmermann U, Müller M
"Molecular aspects of tinnitus."
Hear Res266p60-9(2010)
Lubka-Pathak M, Shah AA, Gallozzi M, Müller M, Zimmermann U, Löwenheim H, Pfister M, Knipper M, Blin N, Schimmang T
"Altered expression of securin (Pttg1) and serpina3n in the auditory system of hearing-impaired Tff3-deficient mice."
Cell Mol Life Scip(2010)
Vandael DH, Marcantoni A, Mahapatra S, Caro A, Ruth P, Zuccotti A, Knipper M, Carbone E
"Ca(v)1.3 and BK channels for timing and regulating cell firing."
Mol Neurobiol42p185-98(2010)
Zampini V, Johnson SL, Franz C, Lawrence ND, Münkner S, Engel J, Knipper M, Magistretti J, Masetto S, Marcotti W
"Elementary properties of CaV1.3 Ca(2+) channels expressed in mouse cochlear inner hair cells."
J Physiol588p187-99(2010)

2009

Heidrych P, Zimmermann U, Kuhn S, Franz C, Engel J, Duncker SV, Hirt B, Pusch CM, Ruth P, Pfister M, Marcotti W, Blin N, Knipper M
"Otoferlin interacts with myosin VI: implications for maintenance of the basolateral synaptic structure of the inner hair cell."
Hum Mol Genet18p2779-90(2009)
Johnson SL, Franz C, Knipper M, Marcotti W
"Functional maturation of the exocytotic machinery at gerbil hair cell ribbon synapses."
J Physiol587p1715-26(2009)
Knipper, M
"Hearing loss - the key healthcare issue in the communication sector...[external content]"
Public Service Review: Science and Technology - Issue 5 (2009)
Kuhn S, Knirsch M, Rüttiger L, Kasperek S, Winter H, Freichel M, Flockerzi V, Knipper M, Engel J
"Ba2+ currents in inner and outer hair cells of mice lacking the voltage-dependent Ca2+ channel subunits beta3 or beta4."
Channels (Austin)3p366-76(2009)
Winter H, Rüttiger L, Müller M, Kuhn S, Brandt N, Zimmermann U, Hirt B, Bress A, Sausbier M, Conscience A, Flamant F, Tian Y, Zuo J, Pfister M, Ruth P, Löwenheim H, Samarut J, Engel J, Knipper M
"Deafness in TRbeta mutants is caused by malformation of the tectorial membrane."
J Neurosci29p2581-7(2009)

2008

Dlugaiczyk J, Singer W, Schick B, Iro H, Becker K, Becker CM, Zimmermann U, Rohbock K, Knipper M
"Expression of glycine receptors and gephyrin in the rat cochlea."
Histochem Cell Biol129p513-23(2008)
Friauf E, Wenz M, Oberhofer M, Nothwang HG, Balakrishnan V, Knipper M, Löhrke S
"Hypothyroidism impairs chloride homeostasis and onset of inhibitory neurotransmission in developing auditory brainstem and hippocampal neurons."
Eur J Neurosci28p2371-80(2008)
Heidrych P, Zimmermann U, Bress A, Pusch CM, Ruth P, Pfister M, Knipper M, Blin N
"Rab8b GTPase, a protein transport regulator, is an interacting partner of otoferlin, defective in a human autosomal recessive deafness form."
Hum Mol Genet17p3814-21(2008)
Hossain A, Hajman K, Charitidi K, Erhardt S, Zimmermann U, Knipper M, Canlon B
"Prenatal dexamethasone impairs behavior and the activation of the BDNF exon IV promoter in the paraventricular nucleus in adult offspring."
Endocrinology149p6356-65(2008)
Johnson SL, Forge A, Knipper M, Münkner S, Marcotti W
"Tonotopic variation in the calcium dependence of neurotransmitter release and vesicle pool replenishment at mammalian auditory ribbon synapses."
J Neurosci28p7670-8(2008)
König O, Rüttiger L, Müller M, Zimmermann U, Erdmann B, Kalbacher H, Gross M, Knipper M
"Estrogen and the inner ear: megalin knockout mice suffer progressive hearing loss."
FASEB J22p410-7(2008)
Lubka M, Müller M, Baus-Loncar M, Hinz M, Blaschke K, Hoffmann W, Pfister M, Löwenheim H, Pusch CM, Knipper M, Blin N
"Lack of Tff3 peptide results in hearing impairment and accelerated presbyacusis."
Cell Physiol Biochem21p437-44(2008)
Panford-Walsh R, Singer W, Rüttiger L, Hadjab S, Tan J, Geisler HS, Zimmermann U, Köpschall I, Rohbock K, Vieljans A, Oestreicher E, Knipper M
"Midazolam reverses salicylate-induced changes in brain-derived neurotrophic factor and arg3.1 expression: implications for tinnitus perception and auditory plasticity."
Mol Pharmacol74p595-604(2008)
Singer W, Panford-Walsh R, Watermann D, Hendrich O, Zimmermann U, Köpschall I, Rohbock K, Knipper M
"Salicylate alters the expression of calcium response transcription factor 1 in the cochlea: implications for brain-derived neurotrophic factor transcriptional regulation."
Mol Pharmacol73p1085-91(2008)

2007

Alavi MV, Bette S, Schimpf S, Schuettauf F, Schraermeyer U, Wehrl HF, Ruttiger L, Beck SC, Tonagel F, Pichler BJ, Knipper M, Peters T, Laufs J, Wissinger B
"A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy."
Brain130p1029-42(2007)
Albert JT, Winter H, Schaechinger TJ, Weber T, Wang X, He DZ, Hendrich O, Geisler HS, Zimmermann U, Oelmann K, Knipper M, Göpfert MC, Oliver D
"Voltage-sensitive prestin orthologue expressed in zebrafish hair cells."
J Physiol580p451-61(2007)
Bette S, Zimmermann U, Wissinger B, Knipper M
"OPA1, the disease gene for optic atrophy type Kjer, is expressed in the inner ear."
Histochem Cell Biol128p421-30(2007)
Bichelmeier U, Schmidt T, Hübener J, Boy J, Rüttiger L, Häbig K, Poths S, Bonin M, Knipper M, Schmidt WJ, Wilbertz J, Wolburg H, Laccone F, Riess O
"Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence."
J Neurosci27p7418-28(2007)
Brandt N, Kuhn S, Münkner S, Braig C, Winter H, Blin N, Vonthein R, Knipper M, Engel J
"Thyroid hormone deficiency affects postnatal spiking activity and expression of Ca2+ and K+ channels in rodent inner hair cells."
J Neurosci27p3174-86(2007)
Knipper M
"[Therapeutic use of stem cells]."
HNO55p845-7(2007)
Knirsch M, Brandt N, Braig C, Kuhn S, Hirt B, Münkner S, Knipper M, Engel J
"Persistence of Ca(v)1.3 Ca2+ channels in mature outer hair cells supports outer hair cell afferent signaling."
J Neurosci27p6442-51(2007)
Lang F, Vallon V, Knipper M, Wangemann P
"Functional significance of channels and transporters expressed in the inner ear and kidney."
Am J Physiol Cell Physiol293pC1187-208(2007)
Rüttiger L, Panford-Walsh R, Schimmang T, Tan J, Zimmermann U, Rohbock K, Köpschall I, Limberger A, Müller M, Fraenzer JT, Cimerman J, Knipper M
"BDNF mRNA expression and protein localization are changed in age-related hearing loss."
Neurobiol Aging28p586-601(2007)
Tan J, Rüttiger L, Panford-Walsh R, Singer W, Schulze H, Kilian SB, Hadjab S, Zimmermann U, Köpschall I, Rohbock K, Knipper M
"Tinnitus behavior and hearing function correlate with the reciprocal expression patterns of BDNF and Arg3.1/arc in auditory neurons following acoustic trauma."
Neuroscience145p715-26(2007)
Winter H, Braig C, Zimmermann U, Engel J, Rohbock K, Knipper M
"Thyroid hormone receptor alpha1 is a critical regulator for the expression of ion channels during final differentiation of outer hair cells."
Histochem Cell Biol128p65-75(2007)

2006

Engel J, Braig C, Rüttiger L, Kuhn S, Zimmermann U, Blin N, Sausbier M, Kalbacher H, Münkner S, Rohbock K, Ruth P, Winter H, Knipper M
"Two classes of outer hair cells along the tonotopic axis of the cochlea."
Neuroscience143p837-49(2006)
Knipper M, Claussen C, Rüttiger L, Zimmermann U, Lüllmann-Rauch R, Eskelinen EL, Schröder J, Schwake M, Saftig P
"Deafness in LIMP2-deficient mice due to early loss of the potassium channel KCNQ1/KCNE1 in marginal cells of the stria vascularis."
J Physiol576p73-86(2006)
Knipper M, Weber T, Winter H, Braig C, Cimerman J, Fraenzer JT, Zimmermann U
"Individual characteristics of members of the SLC26 family in vertebrates and their homologues in insects."
Novartis Found Symp273p19-30; discussion 30-41, 261-4(2006)
Schick B, Starlinger V, Haberle L, Eigenthaler M, Walter U, Knipper M
"Delayed formation of actin filaments in the outer pillar head plate of VASP-/- mice."
Cells Tissues Organs184p88-95(2006)
Schug N, Braig C, Zimmermann U, Engel J, Winter H, Ruth P, Blin N, Pfister M, Kalbacher H, Knipper M
"Differential expression of otoferlin in brain, vestibular system, immature and mature cochlea of the rat."
Eur J Neurosci24p3372-80(2006)
van Wijk E, van der Zwaag B, Peters T, Zimmermann U, Te Brinke H, Kersten FF, Märker T, Aller E, Hoefsloot LH, Cremers CW, Cremers FP, Wolfrum U, Knipper M, Roepman R, Kremer H
"The DFNB31 gene product whirlin connects to the Usher protein network in the cochlea and retina by direct association with USH2A and VLGR1."
Hum Mol Genet15p751-65(2006)
Winter H, Braig C, Zimmermann U, Geisler HS, Fränzer JT, Weber T, Ley M, Engel J, Knirsch M, Bauer K, Christ S, Walsh EJ, McGee J, Köpschall I, Rohbock K, Knipper M
"Thyroid hormone receptors TRalpha1 and TRbeta differentially regulate gene expression of Kcnq4 and prestin during final differentiation of outer hair cells."
J Cell Sci119p2975-84(2006)

2005

Löwenheim H, Reichl J, Winter H, Hahn H, Simon C, Gültig K, Müller A, Zenner HP, Zimmermann U, Knipper M
"In vitro expansion of human nasoseptal chondrocytes reveals distinct expression profiles of G1 cell cycle inhibitors for replicative, quiescent, and senescent culture stages."
Tissue Eng11p64-75(2005)
Reiners J, van Wijk E, Märker T, Zimmermann U, Jürgens K, te Brinke H, Overlack N, Roepman R, Knipper M, Kremer H, Wolfrum U
"Scaffold protein harmonin (USH1C) provides molecular links between Usher syndrome type 1 and type 2."
Hum Mol Genet14p3933-43(2005)
Reisinger E, Zimmermann U, Knipper M, Ludwig J, Klöcker N, Fakler B, Oliver D
"Cod106, a novel synaptic protein expressed in sensory hair cells of the inner ear and in CNS neurons."
Mol Cell Neurosci28p106-17(2005)

2004

Bildl W, Strassmaier T, Thurm H, Andersen J, Eble S, Oliver D, Knipper M, Mann M, Schulte U, Adelman JP, Fakler B
"Protein kinase CK2 is coassembled with small conductance Ca(2+)-activated K+ channels and regulates channel gating."
Neuron43p847-58(2004)
Carnicero E, Zelarayan LC, Rüttiger L, Knipper M, Alvarez Y, Alonso MT, Schimmang T
"Differential roles of fibroblast growth factor-2 during development and maintenance of auditory sensory epithelia."
J Neurosci Res77p787-97(2004)
Katz E, Elgoyhen AB, Gómez-Casati ME, Knipper M, Vetter DE, Fuchs PA, Glowatzki E
"Developmental regulation of nicotinic synapses on cochlear inner hair cells."
J Neurosci24p7814-20(2004)
Rüttiger L, Sausbier M, Zimmermann U, Winter H, Braig C, Engel J, Knirsch M, Arntz C, Langer P, Hirt B, Müller M, Köpschall I, Pfister M, Münkner S, Rohbock K, Pfaff I, Rüsch A, Ruth P, Knipper M
"Deletion of the Ca2+-activated potassium (BK) alpha-subunit but not the BKbeta1-subunit leads to progressive hearing loss."
Proc Natl Acad Sci U S A101p12922-7(2004)
Schick B, Praetorius M, Eigenthaler M, Jung V, Müller M, Walter U, Knipper M
"Increased noise sensitivity and altered inner ear MENA distribution in VASP-/- mice."
Cell Tissue Res318p493-502(2004)

2003

Bartolami S, Augé C, Travo C, Ventéo S, Knipper M, Sans A
"Vestibular Schwann cells are a distinct subpopulation of peripheral glia with specific sensitivity to growth factors and extracellular matrix components."
J Neurobiol57p270-90(2003)
Oliver D, Knipper M, Derst C, Fakler B
"Resting potential and submembrane calcium concentration of inner hair cells in the isolated mouse cochlea are set by KCNQ-type potassium channels."
J Neurosci23p2141-9(2003)
Rüttiger L, Ciuffani J, Zenner HP, Knipper M
"A behavioral paradigm to judge acute sodium salicylate-induced sound experience in rats: a new approach for an animal model on tinnitus."
Hear Res180p39-50(2003)
Schick B, Praetorius M, Eigenthaler M, Mack A, Plinkert P, Walter U, Dazert S, Knipper M
"Expression of VASP and zyxin in cochlear pillar cells: indication for actin-based dynamics?"
Cell Tissue Res311p315-23(2003)
Schimmang T, Tan J, Müller M, Zimmermann U, Rohbock K, Kôpschall I, Limberger A, Minichiello L, Knipper M
"Lack of Bdnf and TrkB signalling in the postnatal cochlea leads to a spatial reshaping of innervation along the tonotopic axis and hearing loss."
Development130p4741-50(2003)
Waka N, Knipper M, Engel J
"Localization of the calcium channel subunits Cav1.2 (alpha1C) and Cav2.3 (alpha1E) in the mouse organ of Corti."
Histol Histopathol18p1115-23(2003)
Weber T, Gopfert MC, Winter H, Zimmermann U, Kohler H, Meier A, Hendrich O, Rohbock K, Robert D, Knipper M
"Expression of prestin-homologous solute carrier (SLC26) in auditory organs of nonmammalian vertebrates and insects."
Proc Natl Acad Sci U S A100p7690-5(2003)

2002

Carnicero E, Knipper M, Tan J, Alonso MT, Schimmang T
"Herpes simplex virus type 1-mediated transfer of neurotrophin-3 stimulates survival of chicken auditory sensory neurons."
Neurosci Lett321p149-52(2002)
Postigo A, Calella AM, Fritzsch B, Knipper M, Katz D, Eilers A, Schimmang T, Lewin GR, Klein R, Minichiello L
"Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons."
Genes Dev16p633-45(2002)
Praetorius M, Knipper M, Schick B, Tan J, Limberger A, Carnicero E, Alonso MT, Schimmang T
"A novel vestibular approach for gene transfer into the inner ear."
Audiol Neurootol7p324-34(2002)
Weber T, Zimmermann U, Winter H, Mack A, Köpschall I, Rohbock K, Zenner HP, Knipper M
"Thyroid hormone is a critical determinant for the regulation of the cochlear motor protein prestin."
Proc Natl Acad Sci U S A99p2901-6(2002)

2001

Knipper M, Richardson G, Mack A, Müller M, Goodyear R, Limberger A, Rohbock K, Köpschall I, Zenner HP, Zimmermann U
"Thyroid hormone-deficient period prior to the onset of hearing is associated with reduced levels of beta-tectorin protein in the tectorial membrane: implication for hearing loss."
J Biol Chem276p39046-52(2001)
Praetorius M, Limberger A, Müller M, Lehner R, Schick B, Zenner HP, Plinkert P, Knipper M
"A novel microperfusion system for the long-term local supply of drugs to the inner ear: implantation and function in the rat model."
Audiol Neurootol6p250-8(2001)

2000

Knipper M, Zinn C, Maier H, Praetorius M, Rohbock K, Köpschall I, Zimmermann U
"Thyroid hormone deficiency before the onset of hearing causes irreversible damage to peripheral and central auditory systems."
J Neurophysiol83p3101-12(2000)
Oestreicher E, Knipper M, Arnold A, Zenner HP, Felix D
"Neurotrophin 3 potentiates glutamatergic responses of IHC afferents in the cochlea in vivo."
Eur J Neurosci12p1584-90(2000)
Zimmermann U, Köpschall I, Rohbock K, Bosman GJ, Zenner HP, Knipper M
"Molecular characterization of anion exchangers in the cochlea."
Mol Cell Biochem205p25-37(2000)

1999 - 1995

Gestwa G, Wiechers B, Zimmermann U, Praetorius M, Rohbock K, Köpschall I, Zenner HP, Knipper M
"Differential expression of trkB.T1 and trkB.T2, truncated trkC, and p75(NGFR) in the cochlea prior to hearing function."
J Comp Neurol414p33-49(1999)
Knipper M, Gestwa L, Ten Cate WJ, Lautermann J, Brugger H, Maier H, Zimmermann U, Rohbock K, Köpschall I, Wiechers B, Zenner HP
"Distinct thyroid hormone-dependent expression of TrKB and p75NGFR in nonneuronal cells during the critical TH-dependent period of the cochlea."
J Neurobiol38p338-56(1999)
Wiechers B, Gestwa G, Mack A, Carroll P, Zenner HP, Knipper M
"A changing pattern of brain-derived neurotrophic factor expression correlates with the rearrangement of fibers during cochlear development of rats and mice."
J Neurosci19p3033-42(1999)
Knipper M, Bandtlow C, Gestwa L, Köpschall I, Rohbock K, Wiechers B, Zenner HP, Zimmermann U
"Thyroid hormone affects Schwann cell and oligodendrocyte gene expression at the glial transition zone of the VIIIth nerve prior to cochlea function."
Development125p3709-18(1998)
Knipper M
"[NT-3 and BDNF for potential inner ear therapy]."
HNO45p181-3(1997)
Knipper M, Rylett RJ
"A new twist in an old story: the role for crosstalk of neuronal and trophic activity."
Neurochem Int31p659-76(1997)
Knipper M, Köpschall I, Rohbock K, Köpke AK, Bonk I, Zimmermann U, Zenner H
"Transient expression of NMDA receptors during rearrangement of AMPA-receptor-expressing fibers in the developing inner ear."
Cell Tissue Res287p23-41(1997)
Knipper M, Zimmermann U, Rohbock K, Köpschall I, Zenner HP
"Expression of neurotrophin receptor trkB in rat cochlear hair cells at time of rearrangement of innervation."
Cell Tissue Res283p339-53(1996)
Knipper M, Zimmermann U, Köpschall I, Rohbock K, Jüngling S, Zenner HP
"Immunological identification of candidate proteins involved in regulating active shape changes of outer hair cells."
Hear Res86p100-10(1995)
Knipper M, Zimmermann U, Rohbock K, Köpschall I, Zenner HP
"Synaptophysin and GAP-43 proteins in efferent fibers of the inner ear during postnatal development."
Brain Res Dev Brain Res89p73-86(1995)

   
 
 
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