Table of Contents

Inner Ear Pharmacology

Prof. Dr. Stefan Plontke, MD

New address:

Universitätsklinik für Hals-Nasen-Ohren-Heilkunde,
Kopf- und Hals-Chirurgie
Ernst-Grube-Str. 40
D-06120 Halle/Saale

phone: +49 (0) 345 / 5571840
telefax: +49 (0) 345 / 5571859
E-Mail: stefan.plontke@uk-halle.de

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http://www.medizin.uni-halle.de/hno/

Selected Publications

Salt AN, Brown DJ, Hartsock JJ, Plontke SK
"Displacements of the organ of Corti by gel injections into the cochlear apex."
Hear Res250p63-75(2009)

Mikulec AA, Plontke SK, Hartsock JJ, Salt AN
"Entry of substances into perilymph through the bone of the otic capsule after intratympanic applications in guinea pigs: implications for local drug delivery in humans."
Otol Neurotol30p131-8(2009)

Plontke SK, Löwenheim H, Mertens J, Engel C, Meisner C, Weidner A, Zimmermann R, Preyer S, Koitschev A, Zenner HP
"Randomized, double blind, placebo controlled trial on the safety and efficacy of continuous intratympanic dexamethasone delivered via a round window catheter for severe to profound sudden idiopathic sensorineural hearing loss after failure of systemic therapy."
Laryngoscope119p359-69(2009)

Salt AN, Gill RM, Plontke SK
"Dependence of hearing changes on the dose of intratympanically applied gentamicin: a meta-analysis using mathematical simulations of clinical drug delivery protocols."
Laryngoscope118p1793-800(2008)

Bullinger D, Fux R, Nicholson G, Plontke S, Belka C, Laufer S, Gleiter CH, Kammerer B
"Identification of urinary modified nucleosides and ribosylated metabolites in humans via combined ESI-FTICR MS and ESI-IT MS analysis."
J Am Soc Mass Spectrom19p1500-13(2008)

Plontke SK, Mikulec AA, Salt AN
"Rapid clearance of methylprednisolone after intratympanic application in humans. Comment on: Bird PA, Begg EJ, Zhang M, et al. Intratympanic versus intravenous delivery of methylprednisolone to cochlear perilymph. Otol Neurotol 2007;28:1124-30."
Otol Neurotol29p732-3; author reply 733(2008)

Hahn H, Kammerer B, DiMauro A, Salt AN, Plontke SK
"Cochlear microdialysis for quantification of dexamethasone and fluorescein entry into scala tympani during round window administration."
Hear Res212p236-44(2006)

Löwenheim H, Reichl J, Winter H, Hahn H, Simon C, Gültig K, Müller A, Zenner HP, Zimmermann U, Knipper M
"In vitro expansion of human nasoseptal chondrocytes reveals distinct expression profiles of G1 cell cycle inhibitors for replicative, quiescent, and senescent culture stages."
Tissue Eng11p64-75(2005)

Plontke S, Siedow N, Hahn H, Wegener R, Zenner HP, Salt AN
"[1D-and 3D- computer simulation for experimental planning and interpretation of pharmacokinetic studies in the inner ear after local drug delivery]."
ALTEX21 Suppl 3p77-85(2004)

Schulte U, Hahn H, Konrad M, Jeck N, Derst C, Wild K, Weidemann S, Ruppersberg JP, Fakler B, Ludwig J
"pH gating of ROMK (K(ir)1.1) channels: control by an Arg-Lys-Arg triad disrupted in antenatal Bartter syndrome."
Proc Natl Acad Sci U S A96p15298-303(1999)

Schulte U, Hahn H, Wiesinger H, Ruppersberg JP, Fakler B
"pH-dependent gating of ROMK (Kir1.1) channels involves conformational changes in both N and C termini."
J Biol Chem273p34575-9(1998)

Oliver D, Hahn H, Antz C, Ruppersberg JP, Fakler B
"Interaction of permeant and blocking ions in cloned inward-rectifier K+ channels."
Biophys J74p2318-26(1998)