Curriculum Vitae – Prof. Dr. rer. nat. Ellen Reisinger

General information


Current Position: W3 Professor, Group Leader

Current Institution:
Eberhard-Karls-Universität Tübingen (EKUT)
Dept of Otolaryngology, Head and Neck Surgery (OHNS)
Molecular Physiology of Hearing
Elfriede-Aulhorn-Str. 5, 72076 Tübingen, DE

ORCID: 0000-0003-3739-7569

AG Reisinger: Gene therapy for hearing loss and deafness

Pubmed

Qualifications and Career

Degree:

1995-2000: Biochemistry (Diploma), Eberhard-Karls University of Tübingen, DE
2005: Doctorate, Supervisor: Prof. Bernd Fakler, Department of Physiology II, Freiburg, DE

Stages of academic/professional carrer:

Since Nov. 2020 : W3-Heisenberg-Professor at the Department for Otorhinolaryngology – Head & Neck Surgery, University Hospital Tübingen, DE
2019-2020 : Visiting Professor for Gene Therapy for Hearing Impairment, Department for Otorhinolaryngology – Head & Neck Surgery, University Hospital Tübingen, DE
2017 : Habilitation in Biochemistry, Georg-August-University Göttingen, DE (mentor: Prof. Tobias Moser)
2009-2019 : Leader of the Molecular Biology of Cochlear Neurotransmission (Junior) Research Group at the Department of Otolaryngology, University of Göttingen Medical Center, DE
2006-2009 : Postdoctoral research fellow at the Department of Otolaryngology, University of Göttingen (Prof. Tobias Moser), and the Department for Molecular Neurobiology of the Max-Planck-Institute for Experimental Medicine, Göttingen, DE (Prof. Nils Brose)
2005-2006 : Postdoctoral research fellow at the Department of Physiology II, University of Freiburg, DE (Prof. Bernd Fakler)

Activities in the Research System

2023 : Member of the CNS and sensory diseases committee for the European Society for Gene and Cell Therapy
2021- : Member of six appointment committees at the Medical Faculty of the University of Tübingen
2021- : Member of the Task Force Technology Transfer of the Medical Faculty of the University of Tübingen
2021- : Member of the Interfaculty Committee and Doctorate Board of the Graduate Training Center of Neurosciences, Tübingen
2021 : Co-Organizer of the Ribbon Synapse Seminar Series (virtual)
2018 : Co-Organizer of the 11th Molecular Biology of Hearing and Deafness conference, Göttingen
2013-2014 : Heidenreich-von-Siebold fellowship of the University Medical Center Göttingen in support of the Habilitation of female scientists
2010-2012 : Mentee in the mentoring program for female scientists of the University Medical Center Göttingen
2009/2011 : Co-Organizer of the Ribbon Synapse Symposium, Göttingen

Activities as Reviewer for funding Agencies:

including: German Research Fondation (DFG), RNID (Royal National Institute for Deaf People) – Fondation pour L’Audition, BSF – United States – Israel Binational Science Foundation

Activities as Reviewer for Journals:

including: Nat Commun, EMBO Mol Med, Am J Hum Genet, Hum Genet, Molr Ther, Int J Nanomedicine, J Neurophysiol, Sci Rep, Front Cell Neurosci, Biochemistry, iScience, Audiology Research (MDPI), eBioMedicine

Academic Distinctions

2023 : Heisenberg-Program extension (2 years), German Research Foundation (DFG)
2022 : Inner Ear Biology, Trieste, Italy, 2022: “Auditory Neuropathy – from basic research to personalized medicine” (Invited Target Lecture)
2021 : 65th Austrian Conference for Otorhinolaryngology, Innsbruck, Austria, “Gentherapie der Taubheit/Gene Therapy for Deafness” (Invited Talk)
2019 : Admission to the Heisenberg-Program, German Research Foundation (DFG)
2013-2014 : Heidenreich-von-Siebold fellowship of the University Medical Center Göttingen in support of the Habilitation of female scientists
2010-2012 : Mentee in the mentoring program for female scientists of the University Medical Center Goettingen
2007 : Travel grant for the 6th Molecular Biology of Hearing and Deafness meeting in Cambridge, UK

Selected publications & Patent

  • Reisinger E, Trapani I (2024) Gene therapy proves successful in treating hereditary deafness. Lancet. 403(10441):2267-2269. DOI: 10.1016/S0140-6736(24)00496-3
  • Stalmann U, Franke AJ, Al-Moyed H, Strenzke N, Reisinger E (2021) Otoferlin is required for proper synapse maturation and for maintenance of inner and outer hair cells in mouse models for DFNB9. Front Cell Neurosci. 15:677543 DOI: 10.3389/fncel.2021.677543 Open Access (planning, supervision of the research, construction of figures, writing – original draft, writing-reviewing and editing)
  • Vona B, Rad A, Reisinger E (2020) The Many Faces of DFNB9: Relating OTOF Variants to Hearing Impairment. Genes (Basel). 11(12):1411. DOI:10.3390/genes11121411 Open Access (conceptualization, data curation, construction of figures, writing – original draft, writing-reviewing and editing)
  • Reisinger E (2020) Dual-AAV delivery of large gene sequences to the inner ear. Hear Res. 394:107857. DOI:10.1016/j.heares.2019.107857 Open Access (review; conceptualization and writing)
  • Al-Moyed H, Cepeda AP, Jung SY, Moser T, Kügler S, Reisinger E (2019) A dual-AAV approach restores fast exocytosis and partially rescues auditory function in deaf otoferlin knock-out mice. EMBO Mol Med. 11(1)pii:e9396. DOI:10.15252/emmm.201809396 Open Access (study design, experiments, data analysis, supervision, original draft, writing-reviewing and editing)
  • Meese S, Cepeda AP, Gahlen F, Adams CM, Ficner R, Ricci AJ, Heller S, Reisinger E, Herget M (2017) Activity-Dependent Phosphorylation by CaMKIIδ Alters the Ca2+ Affinity of the Multi-C2-Domain Protein Otoferlin. Front Synaptic Neurosci. 9:13. DOI: 10.3389/fnsyn.2017.00013 Open Access (study design, supervision of experiments, data analysis, original draft, writing-reviewing and editing)
  • Strenzke N, Chakrabarti R, Al-Moyed H◊, Müller A, Hoch G, Pangrsic T, Yamanbaeva G, Lenz C, Pan KT, Auge E, Geiss-Friedlander R, Urlaub H, Brose N, Wichmann C, Reisinger E (2016) Hair cell synaptic dysfunction, auditory fatigue and thermal sensitivity in otoferlin Ile515Thr mutants. EMBO J. 35(23):2519-2535. DOI:10.15252/embj.201694564 (research design, data analysis, experiments, writing/ editing, supervision, management and coordination, funding)
  • Pangršič T, Reisinger E, Moser T (2012) Otoferlin: a multi-C2 domain protein essential for hearing. Review, Trends Neurosci. 35(11):671-80. DOI:10.1016/j.tins.2012.08.002 (conceptualizaton, data curation, writing- orginal draft and editing)
  • Reisinger E, Bresee C, Neef J, Nair R, Reuter K, Bulankina AV, Nouvian R, Koch M, Bückers J, Kastrup L, Roux I, Petit C, Hell SW, Brose N, Rhee JS, Kügler S, Brigande JV, Moser T (2011) Probing the functional equivalence of otoferlin and synaptotagmin 1 in exocytosis. J Neurosci. 31(13):4886-4895. DOI:10.1523/JNEUROSCI.5122-10.2011 (research design, experiments, data analysis, writing- original draft, writing- review and editing)
  • Helfmann S, Neumann P, Tittmann K, Moser T, Ficner R, Reisinger E (2011) The Crystal Structure of the C2A Domain of Otoferlin Reveals an Unconventional Top Loop Region. J Mol Biol. 406:479-490. DOI:10.1016/j.jmb.2010.12.031 (study design, data analysis, writing- orginal draft, writing- review and editing)
  • Pangršič T, Lasarow L, Reuter K, Takago H, Schwander M, Riedel D, Frank T, Tarantino LM, Bailey JS, Strenzke N, Müller U, Brose N, Reisinger E, Moser T(2010) Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells. Nat Neurosci. 13(7):869-76. DOI:10.1038/nn.2578 (study design, generated the knockout mice, writing- review and editing)


Patent

(International Patent, pending) Simons EJ, Ng R, Reisinger E, Al-Moyed H, Kügler S; Compositions and methods for treating non-age-associated hearing impairment in a human subject. US Patent App. 16/971,922